Also, treating patients with Nevirapine (an AIDS drug) when already on Rifamycin, a TB drug, would be a problem. That is because Rifamycin induces some enzymes which in turn metabolise Nevirapine. Hence the level of Nevirapine in the blood drops, making it very favourable for HIV to mutate and develop drug resistance.
Use of efavirenz along with these drugs reduced this problem , hence safe for treating co infection
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